ODCs

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1 OMIM reference -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 1

3 associated genes
7 signs/symptoms

Premature chromosome condensation with microcephaly and intellectual deficit

Mantle cell lymphoma


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MCPH1	(0.52)	ATM

Citations in the biomedical literature:

Premature chromosome condensation with microcephaly and intellectual deficit		Mantle cell lymphoma
	Synonym(s): (no synonyms)		Synonym(s): - LCM - MCL - Mantle zone lymphoma

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Neoplasms -

	Epidemiological data: (no data available)		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial

	External references: 1 OMIM reference - No MeSH references		External references: No OMIM references 1 MeSH reference: D020522

Premature chromosome condensation with microcephaly and intellectual deficit		Mantle cell lymphoma
	Very frequent - Autosomal recessive inheritance - Chromosomal or genetic anomaly - Downslanted palpebral fissures / anti-mongoloid slanting palpebral fissures - Intellectual deficit / mental / psychomotor retardation / learning disability - Microcephaly - Short stature / dwarfism / nanism - Sloping forehead - Thin / retracted lips Frequent - Agenesis / hypoplasia / aplasia of kidneys - Corpus callosum / septum pellucidum total / partial agenesis - Cortical anomaly / thick bone cortical layer - Dilated cerebral ventricles without hydrocephaly - Hypereflexia - Ureter / calyx / pelvis duplication / bifid / retrocava / retroiliac ureter		Very frequent - Hematologic / blood / lymphatic cancer - Lymphadenopathy / polyadenopathies Frequent - Anorexia - Asthenia / fatigue / weakness - Bone marrow / medullar infiltration - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration